ÿþ<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3c.org/TR/1999/REC-html401-19991224/loose.dtd"> <!-- Created from PDF via Acrobat SaveAsXML --><!-- Mapping table version: 28-February-2003 --><HTML xmlns="http://www.w3.org/TR/REC-html40" xmlns:v = "urn:schemas-microsoft-com:vml" xmlns:o = "urn:schemas-microsoft-com:office:office" xmlns:w = "urn:schemas-microsoft-com:office:word"><HEAD> <META http-equiv=Content-Type content="text/html; charset=unicode"> <META content=Word.Document name=ProgId> <META content="MSHTML 6.00.6000.16674" name=GENERATOR> <META content="Microsoft Word 10" name=Originator><LINK href="abstract%208_3_4-Dateien/filelist.xml" rel=File-List><!--[if gte mso 9]><xml> <o:DocumentProperties> <o:Author>Kurt Ammer</o:Author> <o:Template>Normal</o:Template> <o:LastAuthor>Kurt Ammer</o:LastAuthor> <o:Revision>9</o:Revision> <o:Created>2008-07-11T11:43:00Z</o:Created> <o:LastSaved>2008-07-11T13:08:00Z</o:LastSaved> <o:Pages>1</o:Pages> <o:Words>587</o:Words> <o:Characters>3705</o:Characters> <o:Lines>30</o:Lines> <o:Paragraphs>8</o:Paragraphs> <o:CharactersWithSpaces>4284</o:CharactersWithSpaces> <o:Version>10.6626</o:Version> </o:DocumentProperties> </xml><![endif]--><!--[if gte mso 9]><xml> <w:WordDocument> <w:Zoom>75</w:Zoom> <w:DontDisplayPageBoundaries/> <w:GrammarState>Clean</w:GrammarState> <w:HyphenationZone>21</w:HyphenationZone> <w:BrowserLevel>MicrosoftInternetExplorer4</w:BrowserLevel> </w:WordDocument> </xml><![endif]--> <STYLE>@font-face { font-family: Garamond; } @page Section1 {size: 595.3pt 841.9pt; margin: 70.85pt 70.85pt 2.0cm 70.85pt; mso-header-margin: 35.4pt; mso-footer-margin: 35.4pt; mso-paper-source: 0; } DIV[class='Part'] { MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; DIRECTION: ltr; TEXT-INDENT: 0px; MARGIN-RIGHT: 0px; TEXT-ALIGN: left } DIV[class='Sect'] { MARGIN-TOP: 0px; MARGIN-BOTTOM: 0px; DIRECTION: ltr; TEXT-INDENT: 0px; MARGIN-RIGHT: 0px; TEXT-ALIGN: left } TABLE { FLOAT: none } P.MsoNormal { FONT-SIZE: 12pt; MARGIN: 0cm 0cm 0pt; COLOR: black; FONT-FAMILY: "Times New Roman"; TEXT-ALIGN: left; mso-style-parent: ""; mso-pagination: widow-orphan; mso-fareast-font-family: "Times New Roman" } LI.MsoNormal { FONT-SIZE: 12pt; MARGIN: 0cm 0cm 0pt; COLOR: black; FONT-FAMILY: "Times New Roman"; TEXT-ALIGN: left; mso-style-parent: ""; mso-pagination: widow-orphan; mso-fareast-font-family: "Times New Roman" } DIV.MsoNormal { FONT-SIZE: 12pt; MARGIN: 0cm 0cm 0pt; COLOR: black; FONT-FAMILY: "Times New Roman"; TEXT-ALIGN: left; mso-style-parent: ""; 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MARGIN: 0cm 0cm 0pt; COLOR: windowtext; FONT-FAMILY: "Courier New"; TEXT-ALIGN: left; mso-pagination: widow-orphan; mso-fareast-font-family: "Times New Roman" } DIV.MsoPlainText { FONT-SIZE: 10pt; MARGIN: 0cm 0cm 0pt; COLOR: windowtext; FONT-FAMILY: "Courier New"; TEXT-ALIGN: left; mso-pagination: widow-orphan; mso-fareast-font-family: "Times New Roman" } P { FONT-SIZE: 12pt; MARGIN: 0cm 0cm 22.4pt 488.8pt; COLOR: black; FONT-FAMILY: "Times New Roman"; TEXT-ALIGN: justify; mso-pagination: widow-orphan; mso-fareast-font-family: "Times New Roman" } SPAN.GramE { mso-style-name: ""; mso-gram-e: yes } DIV.Section1 { page: Section1 } </STYLE> <!--[if gte mso 10]> <style> /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Normale Tabelle"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman";} </style> <![endif]--> <META content=Kurt name=dc.creator> <META content="Dermatoscopy and thermal imag..." name=dc.title> <META content=2008-07-10T17:11:38+02:00 name=dc.date> <META content=2008-07-10T17:11:38+02:00 name=dc.date.modified><!--[if gte mso 9]><xml> <o:shapedefaults v:ext="edit" spidmax="5122"/> </xml><![endif]--><!--[if gte mso 9]><xml> <o:shapelayout v:ext="edit"> <o:idmap v:ext="edit" data="1"/> </o:shapelayout></xml><![endif]--></HEAD> <BODY lang=DE style="tab-interval: 35.4pt" vLink=purple aLink=#f0000a link=blue bgColor=white> <DIV class=Section1> <DIV> <H2 style="MARGIN: 0cm 38pt 18pt 26.95pt"><SPAN lang=EN-GB style="FONT-WEIGHT: normal; FONT-SIZE: 16pt; FONT-FAMILY: Garamond; mso-ansi-language: EN-GB">Dermatoscopy and thermal imaging: a comparative investigation of melanocytic nevi of the skin </SPAN><SPAN lang=EN-GB style="FONT-SIZE: 16pt; mso-ansi-language: EN-GB"><o:p></o:p></SPAN></H2> <P style="MARGIN: 0cm 38pt 12pt 26.95pt; TEXT-ALIGN: left" align=left><SPAN lang=EN-GB style="FONT-SIZE: 14pt; FONT-FAMILY: Garamond; mso-ansi-language: EN-GB">Danuta Mikulska </SPAN><SPAN lang=EN-GB style="FONT-SIZE: 14pt; mso-ansi-language: EN-GB"><o:p></o:p></SPAN></P> <DIV> <P class=MsoPlainText style="MARGIN: 0cm 38pt 0pt 27pt"><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">Summary<o:p></o:p></SPAN></P> <P class=MsoPlainText style="MARGIN: 0cm 38pt 6pt 27pt"><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">BACKGROUND: Thermography is a noninvasive technology for accurate registration of temperature distribution of the surface of the body studied. <o:p></o:p></SPAN></P> <P class=MsoPlainText style="MARGIN: 0cm 38pt 6pt 27pt"><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">METHODS: The study enrolled 245 patients with 735 melanocytic nevi and 12 patients with malignant melanoma. All melanocytic lesions were studied with a dermatoscope and<SPAN style="mso-spacerun: yes">&nbsp; </SPAN>an thermal imager. A Heine delta 10 dermatoscope<SPAN style="mso-spacerun: yes">&nbsp; </SPAN>was used to determine the TDS (total dermatoscopy score  according to Stolz) coefficient.<SPAN style="mso-spacerun: yes">&nbsp; </SPAN>A<SPAN style="mso-spacerun: yes">&nbsp; </SPAN>ThermaCAMTM S.C. 500 thermographic camera measured the maximum (Tmax), minimum (Tmin), and average temperatures in the area of the melanocytic lesions. The range of temperatures was calculated by<SPAN style="mso-spacerun: yes">&nbsp; </SPAN>the difference of<SPAN style="mso-spacerun: yes">&nbsp; </SPAN>maximum and minimum temperatures shown as </SPAN><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Symbol; mso-ascii-font-family: Garamond; mso-hansi-font-family: Garamond; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font-family: Symbol">D</SPAN></SPAN><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">T (°C)=Tmax-Tmin. Histopathological evaluation was performed in 127 surgically excised melanocytic nevi and 12 malignant melanomas. According to the dematoscopic score lesions were allocated in three groups labelled  benign ,  suspicious and  malign .The comparative analysis of mean values between the groups was performed with  Student t- test, and Pearson coefficient (r) was applied to test the linear correlation between the variables. <o:p></o:p></SPAN></P> <P class=MsoPlainText style="MARGIN: 0cm 38pt 6pt 27pt"><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">RESULTS: Positive correlations were found between the results of dermoscopic and thermographic examination of the melanocytic nevi (p&lt;0.001). <o:p></o:p></SPAN></P> <P class=MsoPlainText style="MARGIN: 0cm 38pt 6pt 26.95pt"><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond"><o:p></o:p></SPAN></P> <P class=MsoPlainText style="MARGIN: 0cm 38pt 6pt 26.95pt"><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">CONCLUSIONS: 1) Infrared thermal imaging may be an adjuvant method of investigation that supports the dermo- scopic evaluation in the diagnosis of atypical (suspicious) melanocytic nevi and other skin lesions suspected for malignancy. 2) The temperature measurement including the </SPAN><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Symbol; mso-ascii-font-family: Garamond; mso-hansi-font-family: Garamond; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font-family: Symbol">D</SPAN></SPAN><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">T (°C) coefficient correlated with the result of the dermoscopic evaluation and TDS score. 3/ Surgery or close follow-up to recognize malignant metaplasia may be applied in cases of the melanocytic nevi with </SPAN><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Symbol; mso-ascii-font-family: Garamond; mso-hansi-font-family: Garamond; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font-family: Symbol">D</SPAN></SPAN><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">T (°C) coefficient &gt;1,4 0C and TDS score&gt; 4.75.<SPAN style="mso-spacerun: yes">&nbsp; </SPAN><o:p></o:p></SPAN></P> <P class=MsoPlainText style="MARGIN: 0cm 38pt 0pt 27pt"><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">KEY WORDS: thermography, atypical melanocytic nevi, dermoscopy<o:p></o:p></SPAN></P> <P class=MsoPlainText style="MARGIN: 0cm 38pt 0pt 27pt"><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond"><o:p>&nbsp;</o:p></SPAN></P> <P class=MsoPlainText style="MARGIN: 0cm 38pt 6pt 26.95pt"><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">DERMATOSKOPIE UND THERMOGRAPHIE: EINE VERGLEICHENDE STUDIE BEI MELANOZYTÄREN HAUTVERÄNDERUNGEN<o:p></o:p></SPAN></P> <P class=MsoPlainText style="MARGIN: 0cm 38pt 6pt 26.95pt"><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">HINTERGRUND: Thermographie ist eine nicht invasive Technik zur genauen Erfassung der Temperaturverteilung an der Oberfläche eines untersuchten Körpers.<SPAN style="mso-spacerun: yes">&nbsp; </SPAN><o:p></o:p></SPAN></P> <P class=MsoPlainText style="MARGIN: 0cm 38pt 6pt 26.95pt"><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">METHODE: 245 Patienten mit<SPAN style="mso-spacerun: yes">&nbsp; </SPAN>735 melanozytischen Naevi und 12 Patienten mit malignem Melanom wurden in die Studie aufgenommen. Alle melanozytische Läsionen wurden mit einem Dermatoskop und einer Infrarotkamera untersucht. Mit einem Heine delta 10 Dermatoskop<SPAN style="mso-spacerun: yes">&nbsp; </SPAN>wurde der TDS- Koeffizient (dermatoskopischer Gesamtskore<SPAN style="mso-spacerun: yes">&nbsp; </SPAN>nach Stolz) bestimmt. Mit einer thermographischen Kamera der Marke ThermaCAMTM S.C. 500 wurden die maximale (Tmax), minimale (Tmin), und durchschnittliche Temperatur innerhalb der melanozytischen Läsion gemessen. Der Temperaturbereich wurde als </SPAN><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Symbol; mso-ascii-font-family: Garamond; mso-hansi-font-family: Garamond; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font-family: Symbol">D</SPAN></SPAN><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">T bestimmt, in dem von der maximalen die minimale Temperatur subtrahiert wurde [</SPAN><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Symbol; mso-ascii-font-family: Garamond; mso-hansi-font-family: Garamond; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font-family: Symbol">D</SPAN></SPAN><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">T (°C)=Tmax-Tmin]. 127 melanozytische Hautveränderungen wurden chirurgisch entfernt und so wie<SPAN style="mso-spacerun: yes">&nbsp; </SPAN>12 Melanome histopathologisch untersucht. Entsprechend des dermatoskopischen Gesamtskores wurden die Läsionen in die Gruppen  gutartig ,  verdächtig und  bösartig eingeteilt. Die vergleichend Analyse der Mittelwerte der Gruppen wurde mit dem Student-T-test durchgeführt, und für<SPAN style="mso-spacerun: yes">&nbsp; </SPAN>lineare Korrelationen wurde der Pearson<SPAN style="mso-spacerun: yes">&nbsp; </SPAN>Koeffizient (<SPAN class=GramE>r )</SPAN>berechnet.<o:p></o:p></SPAN></P> <P class=MsoPlainText style="MARGIN: 0cm 38pt 6pt 26.95pt"><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">ERGEBNISSE: Positive Korrelationen wurden zwischen den dermatoskopischen und den thermograpischen Er- gebnissen gefunden (p&lt;0.001). <o:p></o:p></SPAN></P> <P class=MsoPlainText style="MARGIN: 0cm 38pt 6pt 26.95pt"><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">SCHLUSSFOLGERUNGEN: 1)Thermographie kann als adjuvante Untersuchungsmethode die Ergebnisse der Dermatoskopie bei der Diagnose atypischer<SPAN style="mso-spacerun: yes">&nbsp; </SPAN>(verdächtiger) melanocytischer Naevi und anderer auf Malignität verdächtiger Hautläsionen stützen. 2) Die Temperaturmessungen einschließlich des Temperaturbereichs </SPAN><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Symbol; mso-ascii-font-family: Garamond; mso-hansi-font-family: Garamond; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font-family: Symbol">D</SPAN></SPAN><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">T (°C) korrelierten mit den Ergebnsissen der Dermatoskopie und dem dermatoskopischen Gesamtskore TDS. 3) Chirugische Excision oder regelmäßige kurzfristige Untersuchungen sollten bei<SPAN style="mso-spacerun: yes">&nbsp; </SPAN>melanozytischen Läsionen mit einem Temperaturbereich<SPAN style="mso-spacerun: yes">&nbsp; </SPAN></SPAN><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Symbol; mso-ascii-font-family: Garamond; mso-hansi-font-family: Garamond; mso-char-type: symbol; mso-symbol-font-family: Symbol"><SPAN style="mso-char-type: symbol; mso-symbol-font-family: Symbol">D</SPAN></SPAN><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">T (°C)&gt;1,4 0C und einem<SPAN style="mso-spacerun: yes">&nbsp; </SPAN>TDS &gt; 4.75 durchgeführt<SPAN style="mso-spacerun: yes">&nbsp; </SPAN>werden, um eine maligne Metaplasie rechtzeitig zu diagnostizieren.<SPAN style="mso-spacerun: yes">&nbsp; </SPAN><o:p></o:p></SPAN></P> <P class=MsoPlainText style="MARGIN: 0cm 38pt 0pt 27pt"><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond">SCHLÜSSELWÖRTER: Thermographie, atypische melanozytische Naevi, Dermatoskopie<o:p></o:p></SPAN></P> <P class=MsoPlainText style="MARGIN: 0cm 38pt 0pt 27pt"><SPAN style="FONT-SIZE: 12pt; FONT-FAMILY: Garamond"><o:p>&nbsp;</o:p></SPAN></P> <P class=MsoPlainText style="MARGIN: 0cm 38pt 0pt 27pt"><SPAN style="FONT-SIZE: 11pt; FONT-FAMILY: Garamond">Thermologie international 2008, 18: 101-106<o:p></o:p></SPAN></P> <DIV> <P style="MARGIN: 0cm 0cm 0pt"><SPAN style="FONT-SIZE: 11pt"><o:p>&nbsp;</o:p></SPAN></P></DIV></DIV></DIV></DIV></BODY></HTML>